Devices for the removal of species from fluids utilizing substantially specific binding means and automatic regeneration means for regeneration of the binding means. The device has utility in preparatory species purification and species collection, in analytical species determination, including diagnostic applications and in fluid purification.

Closed regeneration device for separating molecules bound substantially specifically to a binding species.

Extracorporeal affinity adsorption methods and devices for removal of species from the blood circulatory system and other biological fluids in the treatment of cancer, atherosclerosis, autoimmune disease, infectious diseases, drug intoxication, liver failure, transplant rejection, and for optimization of targeting of treatment and diagnostic agents, particularly in cancer.

Methods of targeting treatment and diagnostic agents.

Methods for improved targeting of drugs and visualization agents, particularly in the treatment of and diagnosis of cancer, including enhanced targeting of liposomes containing drugs and of liposomes containing diagnostic agents.

Immunoassay methods utilizing double and multiple antibody assays for enhanced specific determination of haptens.

Immunoassays using latex agglutination for assaying of psychoactive drugs.

Liposome preparations with enhanced targeting efficacy and methods for their utilization in the treatment and diagnosis, particularly of cancer.